The best times to make a trip to Rome, Italy, are April through May and September through mid-October. These months have the best weather of the year, with mild temperatures that aren’t too hot, allowing you to spend the whole day exploring and checking out the many attractions.Traveling during summer can be extremely uncomfortable as temperatures can soar above 100°F or higher. The month of August is also somewhat of a ghost town as Roman people take a month-long vacation. Winter travel to Rome is the best time to avoid crowds, but these months are cooler and much rainier.